Recent scientific research suggests that the body responds favorably to CBD. Introducing CBD to the body may reduce the symptoms of a wide range of conditions, such as epilepsy, multiple sclerosis, chronic inflammation, depression, diabetes, rheumatoid arthritis, anxiety, and opioid withdrawal.


CBD acts upon CB1 and CBD2 receptors located throughout the body to produce a variety of potentially indirect but positive outcomes.


CBD has the capability to activate TRPV1 receptors that work to manage vital functions like pain perception, body temperature, and inflammation. CBD may also increase the amount of anandamide, which plays a central role in the neural development of pleasure and motivation.


By stimulating the endocannabinoid system, CBD promotes homeostasis, reduces pain sensation, and decreases inflammation.

Effects of CBD on the Endocannabinoid System

The endocannabinoid system responds to endogenous cannabinoids that the body produces.


Extensive research has revealed that the system recognizes and responds to cannabinoids from extrinsic sources, including CBD. Manipulating the endocannabinoid system by introducing external cannabinoids like CBD may be useful in treating a variety of medical ailments, such as (partial list):


Chronic pain


Multiple Sclerosis


Parkinson’s Disease




Bone Fractures

Mad Cow Disease

Clinical Depression

Bacterial Infections

Type II Diabetes





Heart Disease




CBD and Cannabinoid Receptors

There are two types of cannabinoid receptors


  1. Cannabinoid receptor type 1 (CB1)
  2. Cannabinoid receptor type 2 (CB2)


Receptors act as locks to certain body functions. Cannabinoids act as keys to unlock those functions. Let’s elaborate on this concept.

Cannabinoid Receptor Type 1 (CB1)

CB1 receptors exist in the brain, intestines, connective tissues, gonads, and various other glands. When activated by CBD, the receptors aid in relieving a wide range of conditions, such as depression, inflammation, high blood pressure, and other conditions.


Activating these receptors also presents health risks such as lowering thyroid hormones, decreased cognitive functions, increased anxiety, less energy, and other conditions.

Cannabinoid Receptor Type 2 (CB2)

CB2 receptors occur in the spleen, tonsils, thymus, and immune cells. A small number exists in the brain. Changes in CB2 receptor functions can trigger almost every type of human disease. CB2 receptors also play roles in liver and kidney function, bone and skin health, cancer, and even pain-related illnesses.


Activating the CB2 receptor with CBD induces a type of white blood cell that destroys the beta-amyloid protein, which is the main component of the plaque found in the brains of people with Alzheimer’s disease. 

Cannabinoids Produced by the Human Body

The human body produces cannabinoids. Endogenous Cannabinoids are neurotransmitters that exist in the body. They attach to cannabinoid receptors in the brain, immune system, and other areas of the body.


Endocannabinoids are key components of cellular membranes that the body creates as the need arises. Endocannabinoids also travel in the opposite direction to other neurotransmitters creating a balancing effect. People taking CBD often comment that they feel more centered or grounded.

CBD’s Indirect Effects on the Endocannabinoid System

Many of the therapeutic benefits of CBD are created through indirect actions, which include activating TRPV1 Receptors. These receptors are involved in regulating pain, body temperature, and inflammation.


CBD also works to inhibit Fatty Acid Amide Hydrolase (FAAH). This inhibition creates higher levels of endocannabinoids like anandamide. Anandamide plays a role in the neural generation of pleasure and motivation. It also performs other important functions like regulating feeding behaviors and assisting with embryo implantation during the early stages of pregnancy.

CBD in Medicine and Health

CBD’s effect on the endocannabinoid system, as well as its impact on other areas of the human body, suggest that it may be useful in treating a multitude of medical conditions. THC may be an effective treatment for multiple ailments, including the side effects of chemotherapy.

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